Translesion polymerase kappa-dependent DNA synthesis underlies replication fork recovery | eLife
Frontiers | DNA Damage Tolerance Pathways in Human Cells: A Potential Therapeutic Target
Translesion polymerase kappa-dependent DNA synthesis underlies replication fork recovery | eLife
Inhibition of Human DNA Polymerases Eta and Kappa by Indole-Derived Molecules Occurs through Distinct Mechanisms
Translesion polymerase eta both facilitates DNA replication and promotes increased human genetic variation at common fragile sites | PNAS
Frontiers | Inhibiting DNA Polymerases as a Therapeutic Intervention against Cancer
Inhibition of mutagenic translesion synthesis: A possible strategy for improving chemotherapy? | PLOS Genetics
DNA polymerases and cancer | Nature Reviews Cancer
Science Signaling - The DNA polymerase Pol-kappa endows tumor cells with resistance to the BRAF inhibitor vemurafenib without increasing mutagenesis, according to new research from the White lab. https://fcld.ly/5jaum2s Credit: K. Temprine
DNA polymerase eta protects human cells against DNA damage induced by the tumor chemotherapeutic temozolomide - ScienceDirect
Translesion polymerase kappa-dependent DNA synthesis underlies replication fork recovery | eLife
IJMS | Free Full-Text | Detours to Replication: Functions of Specialized DNA Polymerases during Oncogene-induced Replication Stress | HTML
DNA Polymerase Kappa Antibody (6F2) (H00051426-M01): Novus Biologicals
Inhibition of Human DNA Polymerases Eta and Kappa by Indole-Derived Molecules Occurs through Distinct Mechanisms | ACS Chemical Biology
Phosphorylation Alters the Properties of Pol η: Implications for Translesion Synthesis
RCSB PDB - 6BS1: Crystal Structure of Human DNA polymerase kappa in complex with DNA containing the major cisplatin lesion
DNA Polymerase Kappa Research Products: Novus Biologicals
Frontiers | Inhibiting DNA Polymerases as a Therapeutic Intervention against Cancer
Molecules | Free Full-Text | Mammalian DNA Polymerase Kappa Activity and Specificity
DNA polymerase η promotes nonhomologous end joining upon etoposide exposure dependent on the scaffolding protein Kap1 - Journal of Biological Chemistry
Translesion polymerase kappa-dependent DNA synthesis underlies replication fork recovery | eLife
DNA polymerase eta: A potential pharmacological target for cancer therapy - Saha - 2021 - Journal of Cellular Physiology - Wiley Online Library
A Small-Molecule Inhibitor of Human DNA Polymerase η Potentiates the Effects of Cisplatin in Tumor Cells | Biochemistry
NF-κB Signaling | NF-kappaB Pathway
Inhibition of mutagenic translesion synthesis: A possible strategy for improving chemotherapy? | PLOS Genetics
DNA polymerase ι is acetylated in response to SN2 alkylating agents | Scientific Reports
DNA polymerase κ: Friend or foe? | Science Signaling
